The science behind it

SYNC-B³®

Specific role played by galectins in inflammation and immune responses and well-known physical and biological properties of bio-molecules, e.g. Chitosan and Hyaluronic Acid.

Introducing into Chitosan a specific molecular tag to enable interaction with galectins and coupling the new material with other well-known bio-molecules, notably Hyaluronic Acid.

  • Osteoarthritis
  • Dermatological diseases
  • Dermo-aesthetic treatments

HYLACH®

Specific role played by galectins in inflammation and immune response, well-known physical, biological properties of HA and well understood safety profile of HA with respect to different body district and different administration routes.

Introducing into Hyaluronic Acid a specific molecular tag to enable interaction with galectins while maintaining the specificity towards the CD44 receptor and the safety profile.

Respiratory tract diseases

Scientific background

The scientific approach of SYNC-B and HYLACH® relies on two factors.

 

The first is related to recent scientific awareness on the involvement of Galectin receptors in many biological processes. For instance, Galectin-1 (GAL-1) and Galectin-3 (GAL-3) have roles in cellular and tissue pathophysiology by organising niches that drive inflammation. The immune response has been published recently (ref. de Oliveira et al; Experim Biol and Medicine, 2015; 240; 1019-1928-Salamanna F et al; J. Cell. Physiol, 2019; 234; 1588-1605)

 

The second factor relates to the chemical-physical and, above all, biological performance carried out by natural biopolymers such as hyaluronic acid (HA) and chitosan (CS). Both polymers are widely used in the medical field thanks to their bio-resorption, biocompatibility and safety. In particular, HA is one of the most widely-used biopolymers in the field of viscosupplementation and chondroprotection for joint pathologies (osteoarthritis), wound care and tissue volume recovery in the field of dermo-aesthetics (bio-revitaliser and dermal filler).

 

Moreover, HA and CS play an important role in tissue regeneration processes. For instance, HA, thanks to the interaction with its receptor (CD44), plays an important role in tuning several biological processes such as cell aggregation, migration, proliferation and activation of cells.