26 Jun The article intitled: ‘Anti-Inflammatory Performance of Lactose-Modified Chitosan and Hyaluronic Mixture in an In Vitro Macrophage-Mediated Inflammation Osteoarthritis Model’, was published on Cells, an open access journal
The article written by researchers of the University of Padua (Italy) was published in the May 2020 issue of Cells (volume 9(6), pages 1328-1342). This study investigates the effects of a mixture if mid-MW hyaluronic acid (HA) in combination with a lactose-modified chitosan (Chitlac®), on pro-inflammatory molecules and metalloproteinases (MMPs) expression, using an in vitro model of macrophage-mediated inflammation.
The results suggest that HA-Chitlac® (mixture attenuated macrophage-induced inflammation, inhibited MMPs expression and exhibited anti-oxidative effects. This evidence provides an initial step toward the development of an early stage osteoarthritis therapeutic treatment.