26 Jun The article intitled: ‘Anti-Inflammatory Performance of Lactose-Modified Chitosan and Hyaluronic Mixture in an In Vitro Macrophage-Mediated Inflammation Osteoarthritis Model’, was published on Cells, an open access journal
Posted at 10:20h in Article
The article written by researchers of the University of Padua (Italy) was published in the May 2020 issue of Cells (volume 9(6), pages 1328-1342). This study investigates the effects of a mixture if mid-MW hyaluronic acid (HA) in combination with a lactose-modified chitosan (Chitlac®), on pro-inflammatory molecules and metalloproteinases (MMPs) expression, using an in vitro model of macrophage-mediated inflammation.
The results suggest that HA-Chitlac® (mixture attenuated macrophage-induced inflammation, inhibited MMPs expression and exhibited anti-oxidative effects. This evidence provides an initial step toward the development of an early stage osteoarthritis therapeutic treatment.